FINAL PROGRAMME ISCD-17

Centro Santa Elisabetta

8.30-9.00        Short Courses Registration
9.00–16.30      Short Courses

Instructors

G. Uccello Barretta        Enantiodiscrimination by NMR spectroscopy

L. Di Bari                        Fundamentals of CD for the determination of absolute configuration and enantiomeric composition

N. Berova                        Structural analysis based on conventional and fluorescence detected CD exciton coupling

G. Pescitelli                    Computation of CD spectra

2.    High performance enantioselective separation processes: theoretical and practical aspects

Instructors

V. Schurig                    Enantioseparations by using capillary GC: present state of the art and future trends

D. W. Armstrong        An introduction and survey of enantioselective liquid chromatography

B. Chankvetadze        Enantioseparations by using capillary electrophoresis: present state of the art and future trends

3.    Chirality in biorecognition

Instructors

J. Caldwell                   Fundamentals of the biological importance of chirality

J. Gal                            Chirality as a modulator of therapeutic and toxic effects of drugs

R.  Corradini                Chirality in DNA targeting

4.    Preparative enantioseparation through HPLC: fundamentals and industrial applications

Instructors

F. Dondi                        Linear and nonlinear chromatography: an introduction to preparative chromatography

A. Cavazzini                  Fundamentals of nonlinear chromatography

M. Morbidelli               Simulated moving bed chromatography for chiral separations

Teatro Regio

15.30-19.00    ISCD-17 Registration Open

17.30–19.00    Welcome Remarks and Presentation of Chirality Medal to Prof. Kenso Soai

    L1 - Asymmetric autocatalysis and its implications in chiral discrimination and the origin of homochirality    

    K. Soai, Dept. of Applied Chemistry, Tokyo University of Science, Tokyo, Japan

19.00-20.30    Chirality Medal Award Reception    

   (Complimentary to all registered participants and accompanying persons)

20.30-21.10    “Corale Verdi” of Parma in concert (Opera airs)    

    (Complimentary to all registered participants and accompanying persons)

Auditorium-Science Campus

Co-Chairs: R. Ungaro  & V. Schurig

9.00 -9.40        L2 - Supramolecular chirality    

    D. N. Reinhoudt, MESA+ Research Institute, University of Twente, Enschede, The Netherlands

9.40-10.20       L3 - Chirality at the interface between crystals and biology    

     L. Addadi, Weizmann Institute of Science, Rehovot, Israel

10.20-10.45     L4 - Explicable and inexplicable chirality: lyotropic liquid crystals formed from helical polymers versus those formed from filamentous viruses    

    M. M. Green, V. Jain, S.  Tomar, L. Day,  Polytechnic University of Brooklyn, New York & Public Health Research Institute, Newark, New Jersey, USA

10.45-11.10    Coffee break

Auditorium-Science Campus

Co-Chairs:  Y. Okamoto & K. Saigo

11.10-11.30    O1 - Supramolecular stereocontrol of chiral cations and applications

    J.  Lacour, Dept. of Organic Chemistry, University of Geneva, Switzerland

11.30-11.50    O2 - A pH switch for chiral recognition in self-assemblies     

    G. Mancini, F. Ceccacci, C. Villani, CNR, Istituto di Metodologie Chimiche, c/o Dip. di Chimica, & Dip. Studi Chimica e Tecnol. Sost. Biologicamente Attive, Università  “La Sapienza”, Roma, Italy

11.50-12.10    O3 - Planar chirality controlled by point chirality in rotaxane    

    T. Takata, Y. Makita, N. Kihara, Tokyo Institute of Technology,Tokyo & Osaka Prefecture University, Osaka, Japan    

12.10-12.30    O4 - Supramolecular assembly of helical polymers    

    E. Yashima, K. Maeda, K. Sakajiri, S. Sakurai, K. Okoshi, M. Ikeda, J. Kumaki, Y. Furusho, Dept. of Molecular Design and Engineering, Nagoya University, & Yashima Super-structured Helix Project, Nagoya, Japan

12.30-12.50    O5 - Conformational manipulation of guest molecules by light–driven chiral molecular scissors     

    K. Kinbara, T. Muraoka, T. Aida, Dept. of Chemistry and Biotechnology, The University of Tokyo &  PRESTO, Japan Science and Technology Agency, Saitama Japan

Faculty of Engineering

Co-Chairs: L. Addadi & N. Harada

11.10-11.30    O6 - Intrinsic birefringence of chiral sodium chlorate crystal     

    R. Kuroda, T. Harada, Graduate School of Arts and Sciences, The University of Tokyo, & Japan Science and Technology Agency, Tokyo, Japan

11.30-11.50    O7 - Enantioselective crystallization on chiral surfaces    

    Y. Mastai, Bar-Ilan University, Ramat-Gan, Israel

11.50-12.10    O8 - Diastereoselectivity in lanthanide based (supra)molecular compounds: from chiral recognition to a new version of helical chirality    

    O. Mamula, M. Lama, Ecole Polytechnique Fédérale de Lausanne, Switzerland

12.10-12.30    O9 - Control of helical chirality in labile octahedral metal complexes by achiral stimuli

    H. Miyake, H. Tsukube, Osaka City University, Osaka, Japan

12.30-12.50    O10 - pH-Triggered molecular propellers    

    J. W. Canary, H. Barcena, Z. Dai, Dept. of Chemistry, New York University, New York, USA

13.00-14.00    Lunch/Vendor Seminars    

    Chiral Technologies - CHIRALPAK® QN-AX and CHIRALPAK® QD-AX : New chiral stationary phases from Daicel specifically designed for chiral acid separation    

    JASCO - Chiral spectroscopic techniques, the hardware aspects    

Faculty of Engineering

14.00-15.00    Poster Session A

Auditorium – Science Campus

Chair: J. Canary

15.00-15.25    L5 - Chiral and optically active persistent chloroorganic pollutants    

    V. A. Nikiforov, St.Petersburg State University, St. Petersburg, Russia

15.25-15.50    L6 - Gas-phase chiral recognition    

    M. Speranza, Dip. di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università di Roma “La Sapienza”, Roma, Italy

15.50-16.10     Coffee Break

Auditorium-Science Campus

Co-Chairs: G. Rosini & T. Ward

16.10-16.30    O11 - Highly potent chiral labelling reagents and application of them to the determination of absolute configurations of natural products and identification of                                            stereoisomers  of  pheromones in the secretion of insects    

    H. Ohrui, K. Akasaka, D. Carlson, G. K. Mori, Tohoku University, Sendai, Japan & U.S. Dept. of Agriculture, Gainesville, Florida, US & Fuji Flavor Co., Ltd., Tokyo,             Japan

16.30-16.50    O12 - Enantiomer separation of 1,4-sulfanylalcohols by cryogenic gas chromatography - YOUNG RESEARCHER HIGHLIGHTS

    J.-J. Filippi, X. Fernandez, A.-M. Loiseau, L. Lizzani-Cuvelier, U. J. Meierhenrich, University of Nice – Sophia Antipolis, ASI Laboratory, Nice, France

16.50-17.10    O13 - Differentiation of chirality of peptide C-terminal residues by NMR using Ce bpba as a chiral shift reagent for aqueous solution    

    K. Omata, N. Hoshi, K. Kabuto, Tohoku University, Dept. of Chemistry, Sendai, Japan

17.10-17.30    O14 - Application of mono-6-deoxy-6-pyridinium-β-cyclodextrins as cationic chiral selectors for the enantioseparation of chiral amino acid derivatives using Capillary                             Electrophoresis    

    T. T. Ong, J. Pang Kwok Hua, S. S. Choo , W. H. Tang, I. M. Wayan, D. J. Young, C. B. Ching, S. C. Ng, Institute of Chemical and Engineering Sciences, & National                 University of Singapore, & Nanyang Technological University, Singapore

17.30-17.50    O15 - Enantiomeric separation of amino acids, N-blocked amino acids, peptides and peptide polymorphisms    

    D. M. Wallworth, J. T. Lee, Advanced Separation Technologies Inc, Whippany, NJ, &  Advanced Separation Technologies Ltd, Congleton, UK

Faculty of Engineering

Co-Chairs: D. Misiti &  J. Gal

16.10-16.30    O16 - Towards the synthesis of pharmacologically active compounds: chiral dirhodium(II) catalyzed asymmetric cyclopropanation of olefins using a new in situ                                         generated phenyliodonium ylides: one pot synthesis and chiral analysis - YOUNG RESEARCHER HIGHLIGHTS

    A. Ghanem, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

16.30-16.50    O17 - Asymmetric synthesis of (+)-chrysanthemic acid promoted by chiral Cu bisoxazoline complexes anchored on solid supports

    S. Carloni, L. Moroni, G. Tanzi, R. Maggi, G. Sartori, V. Borzatta, ENDURA S.p.A., Ravenna & Dip. di Chimica Organica e Industriale dell’Università, Parma, Italy

16.50-17.10    O18 - Highly enantioselective pinacol coupling reaction promoted by novel low-valent titanium–(R,R)-3,3'-bisBINOL complex

    T. Kawanami, K. Ishizuka, H. Furuno, J. Inanaga, Dept. of Molecular Chemistry & Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, Japan

17.10-17.30    O19 - Fast screening of chiral HPLC separation conditions: application for alcohol dehydrogenase reaction    

    A. L. L. Duchateau, S. M. A. de Wildeman, W. A. F. Koolen, DSM Pharma Chemicals, Geleen, The Netherlands

17.30-17.50    O20 - Optically pure furyl hydroperoxides from the chiral pool as renewable stereoselective oxygen donors    

    A. Lattanzi, S. Piccirillo, A. Scettri, Dept. of Chemistry, University of Salerno, Baronissi, Italy    

Auditorium – Science Campus

Chairman: F. Gasparrini

17.50-18.30    L7 - Comparison of molecular recognition in the gas phase versus solution phase investigated by Mass Spectrometry and Liquid Chromatography using cinchonane                             derivatives as chiral selectors    

    W. Lindner, K. Schug, P. Fryčák, N. M. Maier, E. Gavioli, Dept. of Analytical Chemistry and Food Chemistry, University of Vienna, Austria

Auditorium – Science Campus

Co-Chairs:  K. Soai & S. Allenmark

9.00- 9.40        L8 - Tuning the chiral recognition ability of polysaccharide-based selectors

     E. Francotte, Novartis Institutes for Biomedical Research, Basel, Switzerland

9.40-10.20       L9 - Advances in enantioselective heterogeneous catalysis    

     P. Salvadori, D. Pini, A. Mandoli, Università di Pisa, Dipartimento di Chimica e Chimica Industriale & C.N.R.-I.C.C.O.M. (Sezione di Pisa), Pisa, Italy

10.20-10.45     L10 - Determination of absolute configuration using Vibrational Circular Dichroism spectroscopy: advantages and limitations    

    P. J. Stephens, Dept. of Chemistry, University of Southern California, Los Angeles, CA, USA

10.45-11.10    Coffee Break

Auditorium – Science Campus

Co-Chairs: N. Berova & P. J. Stephens

11.10-11.30    O21 - How can we challenge the ultimate chirality by chemical and spectroscopic methods?    

    N. Harada, M. Akagi, S. Sekiguchi, J. Naito, Y. Yamamoto, H. Taji, M. Watanabe, Inst. of Multidisciplinary Res. for Advanced Materials, Tohoku University, Sendai, Japan

11.30-11.50    O22 - Exploring the limits and limitations of VCD    

    L. Nafie, T. Freedman, X. Cao, R. Lombardi, Y. He, R. Dukor, Dept. of Chemistry, Syracuse University, Syracuse, NY, & BioTools, Inc., Wauconda, IL, USA

11.50-12.10    O23 - Determination of the absolute configuration of three as-hydrindacene compounds by Vibrational Circular Dichroism    

    T. Kuppens, K. Vandyck, W. Herrebout, P. Bultinck, Dept. of Inorganic and Physical Chemistry, & Dept. of Organic Chemistry, Ghent University, Ghent; & Dept. of Chemistry, Universiteit Antwerpen, Antwerp, Belgium

12.10-12.30    O24 - Absolute configuration modulation excitation ATR-IR spectroscopy: a powerful tool for the investigation of enantiodiscriminating interactions at chiral                                         solid-liquid interfaces     

    T. Bürgi, M. Bieri, Université de Neuchâtel, Institut de Chimie, Neuchâtel, Switzerland

12.30-12.50    O25 - Enhancement of both sensitivity and enantioselectivity of chiral sensor having phenolic pseudo-18-crown-6 ether structure with a fluorescent, conjugated polymer                         backbone    

    K. Hirose, S. Miura, Y. Senda, Y. Tobe, Graduate School of Engineering Science, Osaka University and CREST (JST), Osaka, Japan

Faculty of Engineering 

Co-Chairs: E. Francotte & D. Armstrong

11.10-11.30    O26 - Chiral switches:  recent developments and challenges    

    I. Agranat, H. Caner, S. R. Wainschtein, Dept. of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel

11.30-11.50    O27 - Effective and practical recovery of the enantiomers of trans-chrysanthemic acid from scalemic and racemic mixtures of industrial source    

    G. Rosini, C. Ayoub, V. Borzatta, E. Marotta, A. Mazzanti, P. Righi, Dip. di Chimica Organica “A. Mangini”, Università di Bologna &  ENDURA S.p.A., Bologna, Italy

11.50-12.10    O28 - Beneficial characteristics of new immobilized polysaccharide-derived CSPs in chiral chromatography    

    T. Zhang, D. Nguyen, P. Franco, Chiral Technologies Europe, Illkirch Cedex, France

12.10-12.30    O29 - Differences in the chiral recognition abilities of coated vs immobilized polysaccharide chiral stationary phases and their application in preparative chiral                                         separations    

    S. Andersson, J. Hashemi, L. Thunberg, Chemical Engineering, Royal Institute of Technology (KTH), Stockholm, & Medicinal Chemistry, AstraZeneca R&D Mölndal, Mölndal, Sweden

12.30-12.50    O30 - Determination of extreme enantiomeric excess in absence of racemic or minor enantiomer reference sample by LC-MS-MS. A case study: Gimatecan and other                         camptothecin derivatives    

    F. Giorgi, E. Badaloni, F. Gasparrini, A. Vigevani, C. Villani, Dept. of Analytical Chemistry, Sigma-Tau S.p.A., Pomezia, & Dip. di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università “La Sapienza”, Roma, Italy

13.00-14.00    Lunch/Vendor Seminar    

    BioTools - Absolute Configuration without Crystallization - The Methodology of VCD

Faculty of Engineering    

14.00-15.00    Poster Session B

Auditorium – Science Campus

Chair: V. Davankov

15.00-15.25    L11 - Scaling exciton couplets for non-covalent interactions    

    M. Simonyi, Chemical Research Centre, Dept. of Bioorganic Chemistry, Budapest, Hungary

15.25-15.50    L12 - Development of Ligand Exchange Chiral Stationary Phases and their Application to the Liquid Chromatographic Resolution of Amino Acids and Hydroxy Acids   

    M. H. Hyun, Y. J. Park, Pusan National University, Busan, Korea    

15.50-16.10     Coffee Break

Auditorium – Science Campus

Co-Chairs: M. H.Hyun & C. Villani

16.10-16.30    O31 - Modified linear dextrins (‘acyclodextrins’) as new chiral selectors for enantioselective gas chromatography    

    G. Sicoli, V. Schurig, Inst. of Organic Chemistry, University of Tübingen, Tübingen, Germany

16.30-16.50    O32 - High-throughput chiral separation by supercritical fluid chromatography

    M. Saito, M. Bounoshita, K. Okamura, T. Miyaji, H. Oda, K. Miyazawa, T. Ishiguro,  JASCO Corporation Tokyo & DAICEL Chemical Industries, Ltd., Niigata, Japan

16.50-17.10    O33 - Mixed cinchona-arylcarbinol-phthalazine-type selectors: towards synthetic receptors with antibody-like chiral recognition capabilities    

    N. M. Maier, E. Gavioli, W. Lindner, University of Vienna, Department of Analytical Chemistry and Food Chemistry, Vienna, Austria

17.10-17.30    O34 - Applicability of polysaccharide derivatives as chiral selectors in enantioselective centrifugal partition chromatography (CPC)     

    E. Pérez, C. Minguillón, Institut de Recerca Biomèdica, Parc Científic de Barcelona & Laboratori de Química Farmacèutica, University of Barcelona, Barcelona, Spain

17.30-17.50    O35 - Automated method development and purification of chiral compounds    

    G. W. Yanik, R. J. Bopp, PDR-Chiral Inc, Lake Park, FL, USA
  

Faculty of Engineering

Co-Chairs: M. Speranza & F. Dondi

16.10-16.30    O36 - Extending the scope of Dynamic Chromatography: fast and precise determination of stereoisomerization barriers with the unified equation

    O. Trapp, Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany

16.30-16.50    O37 - Enantiophore modelling: a data mining approach in HPLC chiral separations  YOUNG RESEARCHER HIGHLIGHTS

    A. Del Rio, C. Roussel, P. Piras, Université ‘Paul Cézanne’, Aix-Marseille III, Marseille Cedex, France

16.50-17.10    O38 - A new microscopic stochastic approach to investigate the configurational stability of enantiomeric drugs by Dynamic Chromatography    

    L. Pasti, M. Pierini, F. Gasparrini, F. Dondi, Dept. of Chemistry, University of Ferrara, Ferrara, & Dip. di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università  La Sapienza. Roma, Italy

17.10-17.30    O39 - Calculation of Raman optical activity using density functional theory     

    J. R. Cheeseman, M. J. Frisch, F. J. Devlin, P. J. Stephens, Gaussian Inc., Wallingford, CT, & University of Southern California, Dept. of Chemistry, Los Angeles, CA, USA

17.30-17.50    O40 - Standard and non-standard elution profiles in chiral chromatography    

    T. Spitzer, Environmental, Industrial and Food Analysis, Helmstedt, Germany

20.30             Gala Dinner at the Castello di Felino  (meeting: 20.00 h)

Auditorium – Science Campus

Co-Chairs: W. Lindner & B. Botta

9.00- 9.40       L13 - Induced chirality in peptide nucleic acid duplexes    

    P. E. Nielsen, Dept. of Medical Biochemistry and Genetics, University of Copenhagen, Blegdamsvej, Denmark

9.40-10.20      L14 - Recent developments in miniaturized enantioseparation techniques    

    B. Chankvetadze, Molecular Recognition and Separation Science Laboratory, Tbilisi State University, Tbilisi, Georgia.

10.20-10.45    L15 - Formation and relevance of D-amino acids in food science and technology    

    H. Brückner, R. Pätzold, Dept. of Food Sciences, University of Giessen, Giessen, Germany

10.45-11.05    Coffee Break

Auditorium – Science Campus

Co-Chairs: C. Welch & M. Simonyi

11.05-11.25    O41 - Chiral photochemistry in supercritical carbon dioxide     

    Y. Inoue, Y. Nishiyama, R. Saito, M. Kaneda, T. Wada, Entropy Control Project, ICORP, JST, Toyonaka & Dept. of Molecular Chemistry, Osaka University, Suita, Japan

11.25-11.45    O42 - Vacuum ultraviolet and soft X-ray circular dichroism of amino acids and asymmetric decomposition induced by circularly polarized light    

    K. Nakagawa, Y. Kodama, M. Tanaka, F. Kaneko, Y. Ohta, T. Kitadab, K. Watanabe, T. Yamada, H. Onuki, A. Agui, K. Fujii, A. Yokoya, Faculty of Human Development, Kobe University, Kobe & Graduate School of Human Science and Cultural studies & Graduate School of Science and Technology, Kobe; &  Advanced Institute of Science and Technology, Tsukuba Ibaraki; &  SPring-8, Japan Atomic Energy Research Institute, Hyogo, Japan

11.45-12.05    O43 - Enthalpic discrimination of liquid (R)- and (S)-enantiomers at 298.15 K    

    T. Kimura, M. A. Khan, M. Ishii, T. Kamiyama, M. Fujisawa, Kinki University, Dept of Chemistry, Higashi-Osaka, Japan

Faculty of Engineering

Chair: P.E. Nielsen

11.05-11.25    O44 - New chiral Peptide Nucleic Acids (PNAs) containing monomers with two stereogenic centres: influence of the configurations on the PNA helical preferences and                         on PNA-DNA duplex stabilities     

    S. Sforza, T. Tedeschi, R. Corradini, A. Dossena, R. Marchelli, University of Parma, Department of Organic and Industrial Chemistry, Parma, Italy.

11.25-11.45    O45 - Using vibrational and electronic circular dichroism in the study of the optical active assemblies of pyrrole derivatives on polypeptides and DNA     

    M. Urbanová, L. Palivec, Inst. of Chemical Technology, Prague, Czech Republic

11.45-12.05    O46 - Vibrational Circular Dichroism spectroscopy of pH dependent structural transitions of polyadenylic acid in solution and film states    

    A. G. Petrovic,  P. L. Polavarapu, Dept. of Chemistry, Vanderbilt University, Nashville, TN, USA

Faculty of Engineering

12.05-13.15    Chirality from the past to the future

    Chairman: D. Misiti

    Participants: V. A. Davankov, L. Di Bari, J. Gal , V. Schurig

13.15-14.15    Lunch

Auditorium– Science Campus

Chair: D. N. Reinhoudt

14.15-14.55     L16 – The inner space of molecules    

    J. Rebek, Jr., The Scripps Research Institute, La Jolla, CA 92037, USA

Auditorium– Science Campus

Chair: P. Salvadori

15.00-15.10    Opening Ceremony

15.10-15.35    L17 - Chiral molecules on Titan: a post-Cassini/Huygens perspective    

    J. I. Lunine, Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ, USA

15.35-16.00    L18 - Chiral diamino acids in the Murchison meteorite and the evolution of genetic material    

    U. J. Meierhenrich, N. Baldovini, G. M. Muñoz Caro, J. H. Bredehöft, E. K. Jessberger, W. H.-P. Thiemann, Faculty of Sciences, University of Nice – Sophia Antipolis, Nice, & Inst. d’Astrophysique Spatiale, Orsay, France & Dept. of Physical Chemistry, University of Bremen, Bremen, &  Westfälische Wilhelms-Universität, Münster, Germany    

16.00-16.20    Coffee break

Auditorium– Science Campus

Chair: P. Salvadori

16.20–16.45     L19 - Consequences of the Soai-reaction: single molecule chirality and re-evaluation of racemates    
16.45–17.25     L20 - Detecting and measuring enantioenrichment on Earth and in space    

   

17.30           Closing Ceremony of ISCD-17 and 4-ISCB    

Invitation to ISCD-18